3D preview of Neural Organ-on-Chip (MEA Substrate + PDMS Microfluidics)
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Neural Organ-on-Chip (MEA Substrate + PDMS Microfluidics)

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Bounding box
60.0 × 40.0 × 2.6 mm
Engine
Precision B-rep
Parameters
26
Published
October 8, 2026

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The prompt

Create a precision CAD model of a neural organ-on-chip based on the attached reference image. The reference image shows the intended existing MEA substrate and general layout. Use it as a visual reference, but create the geometry as an editable parametric CAD model. The device consists of: 1. Rigid glass or silicon MEA substrate as the bottom layer. 2. A PDMS microfluidic layer positioned directly on top of the MEA substrate. 3. A central rectangular neural culture chamber positioned directly over the MEA electrode region. 4. Two separate inlet ports on one side: - Inlet A: exposure medium - Inlet B: control/reference medium 5. Two narrow inlet channels that merge smoothly into a symmetric Y-junction. 6. One main microfluidic channel extending from the Y-junction into the central neural culture chamber. 7. One outlet channel leaving the opposite side of the culture chamber and ending at a single outlet port. 8. Inside the central culture region, create a set of narrow parallel microtunnels connecting the main culture compartments. The microtunnels should be clearly smaller than the main fluidic channels and arranged symmetrically. 9. Use the microtunnels to create two distinguishable neural culture compartments on either side of the central microtunnel region. 10. Keep the MEA electrode array underneath the neural culture region so that electrical recording from the cultured neural region is represented by the underlying MEA. Overall architecture: Inlet A ──╲ ╲ ╲ Y ───── main channel ───── culture chamber ───── outlet ╱ │ ╱ microtunnels Inlet B ──╱ between compartments IMPORTANT: - Do not create decorative geometry. - Do not use arbitrary biological dimensions. - Use reasonable editable CAD dimensions in millimeters where dimensions are not specified. - Keep the culture chamber centered over the MEA. - Keep the two inlet branches symmetric. - Keep the outlet opposite the inlets. - Microtunnels must be visibly narrower than the main channels. - Keep all major components as separate, identifiable parametric features where possible. - Make the model suitable for a scientific project presentation. - Do not add pumps, tubing, cells, or other components not requested.

Parameters

NameValueRange
Substrate Length (X)60 mm20 – 200
Substrate Width (Y)40 mm20 – 200
Substrate Thickness1.1 mm0.3 – 5
PDMS Length (X)50 mm20 – 200
PDMS Width (Y)30 mm15 – 200
PDMS Thickness1.5 mm0.5 – 8
Slab Corner Fillet1.5 mm0 – 8
Channel Width0.4 mm0.05 – 3
Channel Depth1.5 mm0.05 – 8
Access Port Diameter2 mm0.4 – 8
Port Distance From Centre18 mm5 – 90
Inlet Port Offset (Y, each side)6 mm0.5 – 40
Y-Junction Position (X)-9 mm-80 – -1
Culture Chamber Length (X)10 mm2 – 60
Culture Chamber Width (Y)6 mm2 – 40
Culture Chamber Depth1.5 mm0.2 – 8
Microtunnel Wall Thickness1 mm0.2 – 6
Microtunnel Width0.1 mm0.02 – 1
Microtunnel Count11 mm1 – 41
Microtunnel Pitch0.4 mm0.05 – 4
Microtunnel Depth1.5 mm0.05 – 8
Electrodes Per Side Per Quadrant3 mm1 – 8
Electrode Pitch0.8 mm0.1 – 5
Electrode Pad Diameter0.4 mm0.05 – 2
First Electrode Offset From Centre0.8 mm0.4 – 20
Electrode Pad Height0.05 mm0.01 – 0.5

Every value above is a live dimension. Open a model like this in the editor and each one becomes a slider you can drag before exporting.

Neural Organ-on-Chip (MEA Substrate + PDMS Microfluidics) - Free CAD Model (STEP, STL) | TextoCAD